On this page you can find factsheets and guidelines with information on many of the different considerations you may be facing when discussing becoming pregnant. The factsheets have all been created from scientific papers and studies released on the topics and collated into a more readable format for you and your healthcare team to discuss together.
You can find references and papers used at the end of the factsheets, or on the Research page.
Information on this page outlines the consensus opinion of the UK MS Pregnancy Register Steering Group (https://pregnancy.ms) and has been produced to help you in your discussions with your MS team.
The safety of medication during pregnancy: A guide for women with multiple sclerosis
You can find the factsheet here
(Last updated October 2025)
Medication and supplementation prior to, during and immediately following pregnancy
You can find the factsheet here
(Last updated May 2025)
Decisions around IVF
You can find the factsheet here
(Last updated May 2025)
Decisions around breastfeeding
You can find the full factsheet here or a condensed version here
(Last updated May 2025)
Guidelines
Please be aware that the ABN pregnancy guidelines are slightly outdated. New guidance is currently being prepared and is expected to be released at the end of 2025 or the beginning of 2026. For anti-CD20 therapies, please refer to the specific guidance for each drug.
Multiple Sclerosis (MS) and Pregnancy. UK ABN consensus guidelines
Summary of Association of British Neurologists guidelines for people with MS.
Developing evidence-based guidelines for the safety of symptomatic drugs in multiple sclerosis during pregnancy and breastfeeding: A systematic review and Delphi consensus
Click here to read more…
We looked at evidence around the safety in pregnancy of symptomatic medications commonly used by people living with MS. We then summarised this, and came up with some guidelines for their use. We used a Delphi technique, which involves asking a range of people for their opinions on the guidelines to try to develop recommendations that were both evidence based and made sense to clinicians and experts in the field.
You can find the abstract here
ABN guidelines for the use of antiCD20 monoclonal antibodies in pregnancy and breastfeeding
Click here to read more…
We reviewed all of the available evidence around the use of anti-CD20 medications in pregnancy and breastfeeding, and developed practical guidelines for clinicians and patients. These were approved by the ABN Advisory group.
You can read the guidelines here
UK consensus on pregnancy in multiple sclerosis: ‘Association of British Neurologists’ guidelines
Click here to read more…
Recommendations for the management of multiple sclerosis (MS) during pregnancy and the postpartum period. The guidelines were developed by a panel of experts in the field of MS and pregnancy, including neurologists, obstetricians, and midwives.
You can read the guidelines here